9,654 RAS Prelims practice MCQs with the correct answer and a clear explanation for each. Filter by subject and chapter.
Practice questions based on the RPSC RAS Prelims syllabus. They follow the exam pattern but are not past-paper questions.
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RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2621. Match List-I with List-II regarding biotech products and their applications:
Biotech product
Medical application
A. Tissue Plasminogen Activator (tPA)
i. Treatment of diabetes mellitus
B. Erythropoietin
ii. Dissolving blood clots in stroke or heart attack patients
C. Interferons
iii. Stimulating red blood cell production in anemia
D. Humulin
iv. Antiviral and anticancer therapies
Explanation
tPA dissolves blood clots in stroke and heart attack patients, erythropoietin stimulates the production of red blood cells in anaemia, interferons are used in antiviral and anticancer therapy and Humulin treats diabetes. This gives A-ii, B-iii, C-iv, D-i.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2622. Gene therapy was first successfully applied clinically in 1990 to treat a four-year-old girl suffering from:
Explanation
The first successful clinical trial of gene therapy was performed in 1990 on a four-year-old girl named Ashanti DeSilva. She suffered from a rare genetic disorder called Severe Combined Immunodeficiency caused by a deficiency of the enzyme Adenosine Deaminase. In the treatment, her own white blood cells were extracted, genetically corrected with a functional ADA gene, and then reinfused to restore function.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2623. Recombinant DNA technology has allowed the development of safer vaccines. The Hepatitis B vaccine is produced using:
Explanation
The modern Hepatitis B vaccine is a recombinant subunit vaccine produced using genetic engineering. The gene for the viruss surface antigen is inserted into common bakers yeast. The yeast cells then produce large quantities of the viral protein, which is harvested and purified for use. Because it only contains a single viral protein and not the whole virus, it is extremely safe.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2624. Which of the following is an advantage of genetically engineered antibiotics over traditional ones?
Explanation
Genetically engineered antibiotics offer the advantage of being produced more efficiently and on a larger scale using optimized microbial hosts. Furthermore, biotechnology allows scientists to specifically modify the structure of existing antibiotics to overcome bacterial resistance mechanisms. While they do not provide complete immunity to resistance, they give researchers a powerful tool to rapidly develop and manufacture new antimicrobial agents.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2625. Hybridoma technology is primarily used for the production of:
Explanation
Hybridoma technology is a specialized technique used to produce large quantities of identical, highly specific antibodies called monoclonal antibodies. This involves fusing a specific antibody-producing cell with a cancerous cell. The resulting hybridoma cell possesses both the antibody specificity and the immortal growth characteristic, allowing for the continuous production of the specific antibody in the laboratory for various medical diagnostic applications.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2626. Identify the incorrect statement regarding gene therapy.
Explanation
Germline gene therapy, which involves modifying the DNA of eggs, sperm, or embryos, is not widely practiced and is actually banned or strictly regulated in most countries due to major ethical and safety concerns. Other statements are correct: gene therapy involves replacing defective genes with functional ones; viral vectors are common delivery tools; and somatic therapy only affects the individual.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2627. The process of analyzing a patient’s genetic profile to tailor medical treatments and drug dosages is known as:
Explanation
Pharmacogenomics is the branch of science that studies how an individuals unique genetic makeup influences their response to drugs. By analyzing a patients DNA, doctors can predict which medications will be most effective and what the optimal dosage should be, while also identifying potential risks for adverse side effects. This approach is a key component of personalized medicine and modern healthcare.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2628. What is a key limitation of using retroviral vectors in gene therapy?
Explanation
A significant risk associated with using retroviral vectors in gene therapy is insertional mutagenesis. Retroviruses work by integrating their genetic material directly into the host cells DNA. However, this integration happens randomly. If the vector accidentally inserts itself into or near a gene that controls cell growth, it could disrupt that genes function and potentially trigger the development of cancer in patients.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2629. Bioremediation is the use of living organisms, primarily microbes, to:
Explanation
Bioremediation is an environmentally friendly technology that utilizes the natural metabolic processes of living organisms, primarily bacteria, fungi, and plants, to clean up contaminated soil, water, and air. These organisms break down, transform, or neutralize hazardous pollutants, such as oil, pesticides, and heavy metals, into less toxic or non-toxic substances, effectively restoring the health of the polluted environment.
RAS PrelimsScience and Technology · Genetics, Biotechnology and Nanotechnology
Q2630. Consider the following statements about bioremediation: I. Pseudomonas putida is a genetically engineered superbug used for cleaning oil spills. II. Bioremediation is generally more cost-effective and eco-friendly than chemical cleanup methods. III. Heavy metals like lead and mercury can be easily completely destroyed by microbial bioremediation. IV. Phytomining uses plants to extract precious metals from low-grade ores. V. Ex-situ bioremediation involves treating contaminated soil at the site without removing it. Which of the above statement(s) is/are correct?
Explanation
Pseudomonas putida is a famous engineered superbug used for oil spills. Bioremediation is typically cheaper and more natural than chemical methods. Phytomining is an innovative use of plants to extract metals. However, heavy metals cannot be destroyed by microbes; they can only be transformed or accumulated. Also, ex-situ bioremediation involves removing contaminated material to another location for treatment.
Answer key for these questions
Q
Correct answer
2621
(a) A-ii, B-iii, C-iv, D-i
2622
(d) Adenosine Deaminase (ADA) deficiency
2623
(a) Yeast cells genetically engineered to produce the viral surface antigen
2624
(b) Large-scale production and modification to combat bacteria
2625
(b) Monoclonal antibodies
2626
(a) Germline gene therapy is widely practiced globally and is free from ethical restrictions.
2627
(c) Pharmacogenomics
2628
(d) Random genomic integration triggering oncogenic changes
2629
(b) Degrade or detoxify environmental pollutants
2630
(a) I, II and IV
Frequently asked questions
How many RAS Prelims practice MCQs are there on RAS Prelims?
This page has 9654 practice MCQs on the RAS Prelims syllabus. Each has the correct answer, and most have an explanation.
How should I practise MCQs for RAS Prelims?
Attempt each question first, then open the answer and read the explanation. Practise one chapter at a time, note the facts you got wrong and revise them. Repeat the chapter after a few days.
Are these actual RAS Prelims past-paper questions?
No. These are practice questions written for the RAS Prelims syllabus. They follow the pattern the exam uses: factual questions, statement-based questions, match-the-list and assertion-reason.
